The Reynolds Lab is examining how immune responses against host proteins can be harnessed to fight AIDS viruses and cancer. Our major research interest is understanding how adaptive immune responses can prevent or eliminate AIDS virus infections through the use of vaccines or novel cure strategies. Additionally, we are using next generation sequencing technologies to identify dog leukocyte antigens (DLA) genes to contribute to comparative oncology and immunotherapy studies in domestic dogs. Lastly, we are also developing platforms to isolate monoclonal antibodies specific for individual non-human primate major histocompatibility (MHC) allomorphs and killer immunoglobulin-like receptors (KIRs). These studies incorporate aspects of immunology, virology, molecular biology, and genomics. Our goal is to identify novel approaches to attack infected or diseased cells that contributes to the fight against important human and veterinary diseases.