Welcome
Welcome to the Reynolds Laboratory
We develop antibody technologies, study HIV latency and cure strategies, and map immune responses to advance therapies for infectious diseases and cancer in humans and animals. Based at the UW-Madison School of Veterinary Medicine and the Wisconsin National Primate Research Center, our work bridges basic immunology and translational science.
Toward a Functional Cure for HIV
Antiretroviral therapy controls HIV but doesn’t eliminate it—the virus persists in latent reservoirs that can reignite infection when treatment stops. A central question for cure research is: how much must we reduce these reservoirs to achieve lasting remission? To address this question, we developed a novel model that lets us establish viral reservoirs of precisely defined sizes, allowing us to determine the reservoir thresholds that could enable people living with HIV to safely stop daily medication.
Isolating Monoclonal Antibodies
We have developed an efficient method to isolate monoclonal antibodies from virtually any species directly from individual B cells. Using this platform, we have generated antibodies against immune molecules that serve as research reagents—and we offer antibody cloning as a service through the Wisconsin National Primate Research Center Immunology Services Unit.
Engineering Bovine Ultralong Antibodies
Cows are central to Wisconsin’s identity as America’s Dairyland, but they may also be a remarkable and largely untapped resource for developing next-generation therapies. Cattle produce antibodies with a unique mushroom-like structure—a stalk topped by a tiny “knob” domain. These knobs are small enough to reach binding sites that conventional antibodies cannot access. In a new area of research, we are harnessing these unique antibodies to develop therapies, including those that target infectious diseases and cancer cells that resist traditional therapies.
About Our Lab
The Reynolds Laboratory is part of the Department of Pathobiological Sciences in the UW-Madison School of Veterinary Medicine. Our research is supported by the National Institutes of Health and builds on over two decades of expertise in immunology and antibody development. We are also a part of the Wisconsin National Primate Research Center’s Immunology Services Unit, providing antibody cloning services to investigators nationwide.